CJC-1295, IPAMORELIN 5/5 (BLEND)

Overview of CJC-1295, Ipamorelin 5/5 (Blend)

CJC-1295, Ipamorelin 5/5 (Blend) is a research peptide combination formulated to support laboratory investigations of coordinated somatotropic axis activation. By combining a GHRH analog with a selective GHS-R1a agonist, this blend enables structured evaluation of dual receptor pathway activation within controlled in vitro experimental models.

The 5mg/5mg composition provides balanced receptor engagement between GHRH-mediated cAMP signaling and ghrelin receptor–mediated calcium signaling pathways, allowing researchers to study complementary intracellular cascade dynamics.

This blend is supplied as a lyophilized sterile powder and is intended strictly for laboratory research and analytical investigation.

Molecular and Receptor Pharmacology

CJC-1295 (Mod GRF 1–29)

CJC-1295 no DAC is a modified 29–amino acid peptide derived from endogenous GHRH. In research models, it selectively activates the GHRH receptor (GHRH-R), stimulating:

• Adenylate cyclase activation

• Cyclic AMP (cAMP) production

• Protein kinase A (PKA) signaling

• Transcriptional regulation of growth hormone pathways

Its shorter-acting profile compared to DAC-bound variants makes it suitable for pulsatile signaling research.

Ipamorelin

Ipamorelin is a synthetic pentapeptide classified as a selective growth hormone secretagogue. It binds to the GHS-R1a receptor and activates:

• Gq/11-mediated phospholipase C signaling

• Inositol triphosphate (IP3) production

• Intracellular calcium mobilization

• Protein kinase C (PKC) cascade activation

Ipamorelin is frequently studied for its receptor selectivity within ghrelin receptor pharmacology models.

Dual-Pathway Mechanism in Research Systems

CJC-1295, Ipamorelin 5/5 (Blend) enables laboratory investigation of two distinct yet complementary signaling mechanisms:

1. GHRH receptor pathway (cAMP/PKA mediated)

2. GHS-R1a pathway (Calcium/PLC mediated)

When activated concurrently in experimental models, researchers may analyze:

• Growth hormone pulsatility simulation

• Intracellular signal amplification

• Receptor cross-talk dynamics

• Hypothalamic–pituitary axis coordination

• Temporal differences in signaling intensity

This dual-activation framework provides insight into endocrine signaling integration within controlled laboratory environments.

Research Applications

CJC-1295, Ipamorelin 5/5 (Blend) is commonly referenced in laboratory investigations involving:

• Somatotropic axis modeling

• GHRH receptor pharmacology

• Ghrelin receptor signaling studies

• Intracellular second messenger pathway analysis

• Endocrine cascade coordination research

• Comparative secretagogue pathway evaluation

In molecular and endocrine research laboratories, this blend serves as a structured model for analyzing complementary peptide-receptor interactions.

Researchers exploring growth hormone regulatory networks frequently reference peer-reviewed scientific databases such as the National Center for Biotechnology Information (NCBI) for foundational literature.

Stability and Laboratory Handling

CJC-1295, Ipamorelin 5/5 (Blend) is supplied as a lyophilized white powder to preserve molecular integrity and enhance storage stability.

Laboratory handling guidelines include:

• Refrigerated storage prior to reconstitution

• Avoidance of repeated freeze–thaw cycles

• Reconstitution with sterile laboratory-grade solvent

• Adherence to institutional peptide handling protocols

Lyophilization ensures reproducible peptide performance across structured experimental applications.

Product Specifications

• Compounds: CJC-1295 (No DAC) + Ipamorelin

• Ratio: 5mg / 5mg

• Classification: Dual growth hormone research peptide blend

• Form: Lyophilized sterile powder

• Appearance: White to off-white solid

• Storage: Refrigerated conditions recommended

• Intended Use: Laboratory research only

Analytical Verification

Each batch undergoes analytical verification to confirm peptide identity and purity, including:

• High-performance liquid chromatography (HPLC)

• Mass spectrometry analysis

• Sequence validation

• Batch-to-batch consistency testing

Lot numbers are assigned to support traceability within formal research documentation.

Compliance Notice

CJC-1295, Ipamorelin 5/5 (Blend) is intended strictly for laboratory research use.

This product is not approved for human consumption, therapeutic application, or clinical use. It is sold exclusively for in vitro research, analytical testing, and scientific investigation by qualified professionals.