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Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

FOX04-DRI 10mg (Proxofim)

$300.00

FOXO4-DRI is a synthetic D-retro-inverso research peptide engineered to selectively interfere with the interaction between FOXO4 and p53 in experimental models. Formulated using D-amino acids to improve proteolytic stability, FOXO4-DRI has been shown in preclinical systems to disrupt p53 nuclear retention, leading to apoptosis in senescent cell populations.

This peptide is widely used in laboratory investigations focused on senolytic pathways, cellular aging processes, and mechanisms related to DNA damage response signaling.

For research use only. Not for human consumption.

References:
Kirkland JL et al., J Clin Invest, 2017;127(4):1247–1256
Yosef R et al., Aging (Albany NY), 2017;9(8):1758–1777
de Keizer PLJ, Trends Mol Med, 2017;23(9):751–762

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FOXO4-DRI 10mg is a synthetic research peptide studied in controlled laboratory environments for its interaction with p53-associated signaling pathways and cellular regulatory mechanisms. In experimental biological systems, FOXO4-DRI 10mg is evaluated for its role in protein–protein interaction research and intracellular transcriptional regulation models.

FOXO4-DRI is a modified peptide designed to interfere with the interaction between FOXO4 and p53 in experimental cellular systems. Laboratory investigations examine how FOXO4-DRI 10mg influences molecular binding dynamics and intracellular signaling cascades within defined in vitro and in vivo research frameworks.


Research Overview

FOXO4-DRI 10mg has been examined in preclinical research exploring transcription factor interaction dynamics and cellular stress–associated signaling pathways. Scientific interest centers on how peptide-mediated interference of FOXO4–p53 interactions affects intracellular regulatory networks under controlled laboratory conditions.

Experimental investigations evaluate molecular markers associated with p53 signaling cascades, transcription factor modulation, and intracellular pathway activation when studying FOXO4-DRI 10mg. These studies are conducted strictly for laboratory research purposes using validated experimental systems.

Research frameworks emphasize structural consistency, receptor-independent protein interaction analysis, and reproducibility across defined cellular models.


Mechanism of Study

The mechanism of study for FOXO4-DRI 10mg involves evaluation of peptide-mediated disruption of FOXO4–p53 protein–protein interactions within experimental systems.

Investigators analyze:

β€’ FOXO4–p53 binding dynamics
β€’ Transcription factor signaling markers
β€’ Intracellular kinase activation pathways
β€’ Cellular stress–associated regulatory cascades
β€’ Downstream transcriptional modulation responses

Laboratory models assess how FOXO4-DRI 10mg influences intracellular signaling networks and protein interaction stability under defined research conditions. These investigations are conducted strictly for laboratory research use.


Structural Characteristics

FOXO4-DRI 10mg is classified as a modified peptide engineered to influence specific protein interaction domains in experimental models. Analytical studies focus on molecular weight confirmation, sequence verification, and chromatographic purity validation to ensure research-grade consistency.

Laboratory characterization frequently includes evaluation of structural stability, peptide solubility properties, and protein interaction specificity across controlled assay environments.


Applications in Research

FOXO4-DRI 10mg is utilized in experimental systems investigating transcription factor regulation, protein–protein interaction dynamics, and intracellular signaling pathway modulation. Researchers may evaluate:

β€’ p53-associated signaling markers
β€’ Cellular regulatory pathway responses
β€’ Transcriptional modulation indicators
β€’ Protein interaction specificity

Laboratory protocols emphasize reproducibility, molecular stability, and pathway-specific analysis within defined research models.


Product Specifications

β€’ 10mg per vial
β€’ Synthetic modified peptide
β€’ Lyophilized powder for enhanced stability
β€’ β‰₯99% HPLC verified purity
β€’ Third-party tested
β€’ Research use only
β€’ Store at -20Β°C

FOXO4-DRI 10mg is supplied in lyophilized form to preserve molecular integrity during storage and transit. Proper laboratory handling procedures are recommended to maintain structural consistency prior to experimental preparation.


Certificate of Analysis

Each batch of FOXO4-DRI 10mg undergoes independent analytical verification to confirm purity and structural identity. High-Performance Liquid Chromatography (HPLC) testing confirms β‰₯99% purity prior to research distribution.

Additional analytical characterization methods may include mass spectrometry and peptide sequence validation procedures to ensure molecular consistency across batches. Certificates of Analysis may be available upon request.


Laboratory Handling & Storage

FOXO4-DRI 10mg should be stored at -20Β°C in a temperature-controlled laboratory environment prior to reconstitution. Lyophilized peptide compounds are formulated to maintain stability when handled according to validated laboratory standards.

Upon preparation for experimental procedures, researchers typically follow established laboratory protocols to preserve structural integrity and ensure reliable analytical outcomes.


Frequently Asked Questions

Q: Is FOXO4-DRI 10mg intended for human consumption?
A: No. This compound is strictly intended for laboratory research use only.

Q: What pathways are evaluated in research studies?
A: Research commonly examines FOXO4–p53 protein interaction dynamics and associated transcriptional regulatory pathways.

Q: How is purity verified?
A: Purity is confirmed through validated High-Performance Liquid Chromatography (HPLC) testing procedures.

For research use only. Not for human consumption.

Weight 1 lbs
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Products will arrive in a lyophilized (powder) form for maximum stability

FOX04-DRI 10mg (Proxofim)
$300.00
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